PDCD1 / PD1 / CD279 (Programmed Cell Death 1) (PDCD1/1410R), CF405S conjugate, 0.1mg/mL

General Information
Description	PD-1 (also known as Programmed Death 1, CD279, and PDCD1) is a negative regulatory T-cell surface receptor. PD-1 is a Type I transmembrane protein expressed on the plasma membrane of T-cells. It is a T-cell checkpoint protein, involved in preventing autoimmunity. Because binding of PD-1 by its ligands PD-L1 or PD-L2 has a suppressive effect on the immune system, inhibition of the PD-1/PD-L1 pathway is a major strategy of immune-oncology therapies. PD-L1 is upregulated in certain cancers, and blocking PD-1 or PD-L1 can inhibit cancer growth. Primary antibodies are available purified, or with a selection of fluorescent CFÂ® dyes and other labels. CFÂ® dyes offer exceptional brightness and photostability. See the CFÂ® Dye Selection Guide for more information. Note: Conjugates of blue fluorescent dyes like CFÂ®405S and CFÂ®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. Stock status: Because Biotium offers a large number of antibody and conjugation options, primary antibody conjugates may be made to order. Typical lead times are up to one week for CFÂ® dye and biotin conjugates, and up to 2-3 weeks for fluorescent protein and enzyme conjugates. Please email order@biotium.com to inquire about stock status and lead times before placing your order. Catalog number key for antibody number 1410, Anti-CD279 (PDCD1/1410R) [table id=253 /]